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| カタログ番号 | HF745014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SASH1 Polyclonal Antibody (HF745014) is a rabbit polyclonal antibody detecting SASH1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SASH1 (Val1091-Met1247). | ||||||||
| ターゲット | SAM and SH3 domain-containing protein 1, Proline-glutamate repeat-containing protein, SASH1, KIAA0790, PEPE1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O94885 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | SAM and SH3 domain-containing protein 1 (SASH1) is a ~136 kDa protein. Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. 1. Dauphinee, SM. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 892-901. PMID: 23776175 2. Zhou, D. et al. (2013) Cellular signalling 25, 1526-38. PMID: 23333244 3. Courcet, JB. et al. (2015) European journal of human genetics : EJHG 23, 957-62. PMID: 25315659 | ||||||||
| 注意事項 | For research use only. |
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