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| カタログ番号 | HC664013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1835 | ||||
| ターゲット | Sodium channel protein type V subunit alpha, SCN5A, Sodium channel protein type 5 subunit alpha, hH1, Voltage-gated sodium channel subunit alpha Nav1.5, Sodium channel protein cardiac muscle subunit alpha | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q14524 | ||||
| RRID | Anti-Human SCN5A Antibody (SAA1835) (abinScience Cat# HC664013, RRID:AB_3727598) |
||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Sodium channel protein type 5 subunit alpha (SCN5A) is a ~226 kDa protein. Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat. 1. Gellens, ME. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 554-8. PMID: 1309946 2. Kattygnarath, D. et al. (2011) Circulation. Cardiovascular genetics 4, 261-8. PMID: 21447824 3. Núñez, L. et al. (2013) Heart rhythm 10, 264-72. PMID: 23085483 4. Chakrabarti, S. et al. (2013) Circulation. Arrhythmia and electrophysiology 6, 392-401. PMID: 23420830 5. Gabelli, SB. et al. (2014) Nature communications 5, 5126. PMID: 25370050 6. Wang, L. et al. (2015) Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 36, 2250-62. PMID: 26279430 7. Musa, H. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 12528-33. PMID: 26392562 8. Kinoshita, K. et al. (2016) Heart rhythm 13, 1113-1120. PMID: 26776555 9. Tan, HL. et al. (2001) Nature 409, 1043-7. PMID: 11234013 10. Wang, DW. et al. (2002) Circulation 105, 341-6. PMID: 11804990 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human SCN5A Antibody (SAA1835)
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