Anti-Human SCN5A Polyclonal Antibody (HC664014)

Name: Anti-Human SCN5A Polyclonal Antibody
Brand: abinScience
SKU: HC664014
Price: 168 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HC664014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SCN5A (Ser1787-Gln1931).

Target

Sodium channel protein type V subunit alpha, SCN5A, Sodium channel protein type 5 subunit alpha, hH1, Voltage-gated sodium channel subunit alpha Nav1.5, Sodium channel protein cardiac muscle subunit alpha

Purification

Purified by antigen affinity column.

Accession

Q14524

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Sodium channel protein type 5 subunit alpha (SCN5A) is a ~226 kDa protein. Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat.

1. Gellens, ME. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 554-8. PMID: 1309946

2. Kattygnarath, D. et al. (2011) Circulation. Cardiovascular genetics 4, 261-8. PMID: 21447824

3. Núñez, L. et al. (2013) Heart rhythm 10, 264-72. PMID: 23085483

4. Chakrabarti, S. et al. (2013) Circulation. Arrhythmia and electrophysiology 6, 392-401. PMID: 23420830

5. Gabelli, SB. et al. (2014) Nature communications 5, 5126. PMID: 25370050

6. Wang, L. et al. (2015) Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 36, 2250-62. PMID: 26279430

7. Musa, H. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 12528-33. PMID: 26392562

8. Kinoshita, K. et al. (2016) Heart rhythm 13, 1113-1120. PMID: 26776555

9. Tan, HL. et al. (2001) Nature 409, 1043-7. PMID: 11234013

10. Wang, DW. et al. (2002) Circulation 105, 341-6. PMID: 11804990

Note

For research use only.

Images

References

Datasheet

Anti-Human SCN5A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human SCN5A Polyclonal Antibody (HC664014)

Overview

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Datasheet

SDS

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