Anti-Human SENP1 Polyclonal Antibody (HP578014)

Name: Anti-Human SENP1 Polyclonal Antibody
Brand: abinScience
SKU: HP578014
Price: 168 USD
Availability: InStock

Datasheet Compartir producto Copiar información

Precio(USD): --

Especificación:

50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HP578014

Descripción

Anti-Human SENP1 Polyclonal Antibody (HP578014) is a rabbit polyclonal antibody detecting SENP1 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human SENP1 (Glu422-Leu644).

Objetivo

Sentrin/SUMO-specific protease SENP1, SENP1, Sentrin-specific protease 1

Purificación

Purified by antigen affinity column.

Número de acceso

Q9P0U3

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Sentrin-specific protease 1 (SENP1) is a ~73 kDa protein. Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity.

1. Gong, L. et al. (2000) The Journal of biological chemistry 275, 3355-9. PMID: 10652325

2. Cheng, J. et al. (2004) Molecular and cellular biology 24, 6021-8. PMID: 15199155

3. Xu, Z. et al. (2005) The Biochemical journal 386, 325-30. PMID: 15487983

4. Kim, YH. et al. (2005) FEBS letters 579, 6272-8. PMID: 16253240

5. Shen, LN. et al. (2006) The Biochemical journal 397, 279-88. PMID: 16553580

6. Hong, Y. et al. (2011) PloS one 6, e23046. PMID: 21829689

7. Cong, L. et al. (2011) The Journal of biological chemistry 286, 43793-43808. PMID: 21965678

8. Li, S. et al. (2013) Oncogene 32, 4883-91. PMID: 23160374

9. Bi, H. et al. (2014) Molecular biology of the cell 25, 2499-508. PMID: 24943844

10. Park, JH. et al. (2014) Nature communications 5, 5483. PMID: 25406032

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human SENP1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human SENP1 Polyclonal Antibody (HP578014)

Vista general

Imágenes

Referencias

Datasheet

SDS