Anti-Human SENP1 Polyclonal Antibody (HP578014)

Name: Anti-Human SENP1 Polyclonal Antibody
Brand: abinScience
SKU: HP578014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Aperçu

Numéro de catalogue

HP578014

Description

Anti-Human SENP1 Polyclonal Antibody (HP578014) is a rabbit polyclonal antibody detecting SENP1 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human SENP1 (Glu422-Leu644).

Cible

Sentrin/SUMO-specific protease SENP1, SENP1, Sentrin-specific protease 1

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9P0U3

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Sentrin-specific protease 1 (SENP1) is a ~73 kDa protein. Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity.

1. Gong, L. et al. (2000) The Journal of biological chemistry 275, 3355-9. PMID: 10652325

2. Cheng, J. et al. (2004) Molecular and cellular biology 24, 6021-8. PMID: 15199155

3. Xu, Z. et al. (2005) The Biochemical journal 386, 325-30. PMID: 15487983

4. Kim, YH. et al. (2005) FEBS letters 579, 6272-8. PMID: 16253240

5. Shen, LN. et al. (2006) The Biochemical journal 397, 279-88. PMID: 16553580

6. Hong, Y. et al. (2011) PloS one 6, e23046. PMID: 21829689

7. Cong, L. et al. (2011) The Journal of biological chemistry 286, 43793-43808. PMID: 21965678

8. Li, S. et al. (2013) Oncogene 32, 4883-91. PMID: 23160374

9. Bi, H. et al. (2014) Molecular biology of the cell 25, 2499-508. PMID: 24943844

10. Park, JH. et al. (2014) Nature communications 5, 5483. PMID: 25406032

Note

For research use only.

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Fiche technique

Anti-Human SENP1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human SENP1 Polyclonal Antibody (HP578014)

Aperçu

Images

Reférences

Fiche technique

SDS