Anti-Human SENP1 Polyclonal Antibody (HP578014)

Name: Anti-Human SENP1 Polyclonal Antibody
Brand: abinScience
SKU: HP578014
Price: 168 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HP578014

説明

Anti-Human SENP1 Polyclonal Antibody (HP578014) is a rabbit polyclonal antibody detecting SENP1 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

種反応性

Human, Mouse

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human SENP1 (Glu422-Leu644).

ターゲット

Sentrin/SUMO-specific protease SENP1, SENP1, Sentrin-specific protease 1

精製

Purified by antigen affinity column.

アクセッション番号

Q9P0U3

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Sentrin-specific protease 1 (SENP1) is a ~73 kDa protein. Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity.

1. Gong, L. et al. (2000) The Journal of biological chemistry 275, 3355-9. PMID: 10652325

2. Cheng, J. et al. (2004) Molecular and cellular biology 24, 6021-8. PMID: 15199155

3. Xu, Z. et al. (2005) The Biochemical journal 386, 325-30. PMID: 15487983

4. Kim, YH. et al. (2005) FEBS letters 579, 6272-8. PMID: 16253240

5. Shen, LN. et al. (2006) The Biochemical journal 397, 279-88. PMID: 16553580

6. Hong, Y. et al. (2011) PloS one 6, e23046. PMID: 21829689

7. Cong, L. et al. (2011) The Journal of biological chemistry 286, 43793-43808. PMID: 21965678

8. Li, S. et al. (2013) Oncogene 32, 4883-91. PMID: 23160374

9. Bi, H. et al. (2014) Molecular biology of the cell 25, 2499-508. PMID: 24943844

10. Park, JH. et al. (2014) Nature communications 5, 5483. PMID: 25406032

注意事項

For research use only.

イメージ

参考文献

データシート

Anti-Human SENP1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-Human SENP1 Polyclonal Antibody (HP578014)

概要

イメージ

参考文献

データシート

SDS