Anti-Human SGMS1 Polyclonal Antibody (HP580014)

Name: Anti-Human SGMS1 Polyclonal Antibody
Brand: abinScience
SKU: HP580014
Price: 168 USD
Availability: InStock

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50ug
100ug

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SDS

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Número de catálogo

HP580014

Descripción

Anti-Human SGMS1 Polyclonal Antibody (HP580014) is a rabbit polyclonal antibody detecting SGMS1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human SGMS1 (Lys2-Ala81).

Objetivo

Sphingomyelin synthase 1, Medulla oblongata-derived protein, Protein Mob, Transmembrane protein 23, Phosphatidylcholine:ceramide cholinephosphotransferase 1, TMEM23, MOB, SMS1, SGMS1

Purificación

Purified by antigen affinity column.

Número de acceso

Q86VZ5

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Phosphatidylcholine:ceramide cholinephosphotransferase 1 (SGMS1) is a ~48 kDa protein. Major sphingomyelin synthase at the Golgi apparatus. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes. Converts the newly synthesized CER, that is transported from the endoplasmic reticulum to the trans-Golgi by the Cer transport protein (CERT), to SM. Can form a heteromeric complex with glucosylceramide synthase (GCS) increasing SMS activity and reducing glucosylceramide synthesis, a critical mechanism that controls the metabolic fate of CER in the Golgi.

1. Huitema, K. et al. (2004) The EMBO journal 23, 33-44. PMID: 14685263

2. Tafesse, FG. et al. (2007) The Journal of biological chemistry 282, 17537-47. PMID: 17449912

3. Yamaoka, S. et al. (2004) The Journal of biological chemistry 279, 18688-93. PMID: 14976195

4. Ding, T. et al. (2008) Journal of lipid research 49, 376-85. PMID: 17982138

5. Ternes, P. et al. (2009) Journal of lipid research 50, 2270-7. PMID: 19454763

6. Hayashi, Y. et al. (2018) The Journal of biological chemistry 293, 17505-17522. PMID: 30242129

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human SGMS1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human SGMS1 Polyclonal Antibody (HP580014)

Vista general

Imágenes

Referencias

Datasheet

SDS