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| カタログ番号 | HP580014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SGMS1 Polyclonal Antibody (HP580014) is a rabbit polyclonal antibody detecting SGMS1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SGMS1 (Lys2-Ala81). | ||||||||
| ターゲット | Sphingomyelin synthase 1, Medulla oblongata-derived protein, Protein Mob, Transmembrane protein 23, Phosphatidylcholine:ceramide cholinephosphotransferase 1, TMEM23, MOB, SMS1, SGMS1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q86VZ5 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Phosphatidylcholine:ceramide cholinephosphotransferase 1 (SGMS1) is a ~48 kDa protein. Major sphingomyelin synthase at the Golgi apparatus. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes. Converts the newly synthesized CER, that is transported from the endoplasmic reticulum to the trans-Golgi by the Cer transport protein (CERT), to SM. Can form a heteromeric complex with glucosylceramide synthase (GCS) increasing SMS activity and reducing glucosylceramide synthesis, a critical mechanism that controls the metabolic fate of CER in the Golgi. 1. Huitema, K. et al. (2004) The EMBO journal 23, 33-44. PMID: 14685263 2. Tafesse, FG. et al. (2007) The Journal of biological chemistry 282, 17537-47. PMID: 17449912 3. Yamaoka, S. et al. (2004) The Journal of biological chemistry 279, 18688-93. PMID: 14976195 4. Ding, T. et al. (2008) Journal of lipid research 49, 376-85. PMID: 17982138 5. Ternes, P. et al. (2009) Journal of lipid research 50, 2270-7. PMID: 19454763 6. Hayashi, Y. et al. (2018) The Journal of biological chemistry 293, 17505-17522. PMID: 30242129 | ||||||||
| 注意事項 | For research use only. |
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