Anti-Human SGTA Polyclonal Antibody (HT125014)

Name: Anti-Human SGTA Polyclonal Antibody
Brand: abinScience
SKU: HT125014
Price: 96 USD
Availability: InStock

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50ug
100ug

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SDS

Aperçu

Numéro de catalogue

HT125014

Description

Anti-Human SGTA Polyclonal Antibody (HT125014) is a rabbit polyclonal antibody detecting SGTA in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human SGTA (Ser84-Pro210).

Cible

SGTA, Small glutamine-rich tetratricopeptide repeat-containing protein alpha, SGT1, SGT, UBP, Alpha-SGT, Vpu-binding protein

Purification

Purified by antigen affinity column.

Numéro d'accès

O43765

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) is a ~34 kDa protein. Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states.

1. Shao, S. et al. (2017) Science (New York, N.Y.) 355, 298-302. PMID: 28104892

2. Mock, JY. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 106-11. PMID: 25535373

3. Leznicki, P. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 19214-9. PMID: 23129660

4. Wunderley, L. et al. (2014) Journal of cell science 127, 4728-39. PMID: 25179605

5. Krysztofinska, EM. et al. (2016) Scientific reports 6, 26433. PMID: 27193484

6. Dutta, S. et al. (2008) Biochemistry 47, 10123-31. PMID: 18759457

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-SGTA polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse brain lysate

Reférences

Fiche technique

Anti-Human SGTA Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human SGTA Polyclonal Antibody (HT125014)

Aperçu

Images

Reférences

Fiche technique

SDS