Human SGTA Recombinant Protein (N-His) (HT125022)

Name: Human SGTA Recombinant Protein (N-His)
Brand: abinScience
SKU: HT125022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HT125022
Description	Recombinant Human SGTA Protein, N-His (HT125022) expressed in E. coli, spanning Ser84-Pro210. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	O43765
Protein length	Ser84-Pro210
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	16.38 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Alpha-SGT, SGT, SGT1, SGTA, Small glutamine-rich tetratricopeptide repeat-containing protein alpha, UBP, Vpu-binding protein
Background	Small glutamine-rich tetratricopeptide repeat-containing protein alpha is a ~34 kDa protein. Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. 1. Shao, S. et al. (2017) Science (New York, N.Y.) 355, 298-302. PMID: 28104892 2. Mock, JY. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 106-11. PMID: 25535373 3. Leznicki, P. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 19214-9. PMID: 23129660 4. Wunderley, L. et al. (2014) Journal of cell science 127, 4728-39. PMID: 25179605 5. Krysztofinska, EM. et al. (2016) Scientific reports 6, 26433. PMID: 27193484 6. Dutta, S. et al. (2008) Biochemistry 47, 10123-31. PMID: 18759457
Note	For research use only

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Datasheet

Human SGTA Recombinant Protein (N-His).pdf

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Human SGTA Recombinant Protein (N-His) (HT125022)

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