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Anti-Human SGTA Polyclonal Antibody (HT125024)

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Vista general
Número de catálogoHT125024
Descripción
Anti-Human SGTA Polyclonal Antibody (HT125024) is a rabbit polyclonal antibody detecting SGTA. Suitable for Mouse, Rat, and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human SGTA (Ser84-Pro210).
Objetivo Alpha-SGT, SGT, SGT1, SGTA, Small glutamine-rich tetratricopeptide repeat-containing protein alpha, UBP, Vpu-binding protein
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso O43765
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) is a ~34 kDa protein. Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states.

1. Shao, S. et al. (2017) Science (New York, N.Y.) 355, 298-302. PMID: 28104892
2. Mock, JY. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 106-11. PMID: 25535373
3. Leznicki, P. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 19214-9. PMID: 23129660
4. Wunderley, L. et al. (2014) Journal of cell science 127, 4728-39. PMID: 25179605
5. Krysztofinska, EM. et al. (2016) Scientific reports 6, 26433. PMID: 27193484
6. Dutta, S. et al. (2008) Biochemistry 47, 10123-31. PMID: 18759457
Nota For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human SGTA Polyclonal Antibody

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