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| カタログ番号 | HT125024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SGTA Polyclonal Antibody (HT125024) is a rabbit polyclonal antibody detecting SGTA. Suitable for Mouse, Rat, and Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human SGTA (Ser84-Pro210). | ||||||||
| ターゲット | Alpha-SGT, SGT, SGT1, SGTA, Small glutamine-rich tetratricopeptide repeat-containing protein alpha, UBP, Vpu-binding protein | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O43765 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) is a ~34 kDa protein. Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. 1. Shao, S. et al. (2017) Science (New York, N.Y.) 355, 298-302. PMID: 28104892 2. Mock, JY. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 106-11. PMID: 25535373 3. Leznicki, P. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 19214-9. PMID: 23129660 4. Wunderley, L. et al. (2014) Journal of cell science 127, 4728-39. PMID: 25179605 5. Krysztofinska, EM. et al. (2016) Scientific reports 6, 26433. PMID: 27193484 6. Dutta, S. et al. (2008) Biochemistry 47, 10123-31. PMID: 18759457 | ||||||||
| 注意事項 | For research use only |
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