Anti-Human SIGLEC8/SAF-2 Recombinant Antibody (SAA0177), APC (HP983137)

Name: Anti-Human SIGLEC8/SAF-2 Recombinant Antibody (SAA0177), APC
Brand: abinScience
SKU: HP983137
Price: 290 USD
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Número de catálogo	HP983137
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	SAA0177
Conjugación	APC
Objetivo	SAF2, Sialoadhesin family member 2, SAF-2, Siglec-8, SIGLEC8, Sialic acid-binding Ig-like lectin 8
Nivel de endotoxinas	Please contact with the lab for this information.
Productos asociados	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), APC
Número de acceso	Q9NYZ4
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Sialic acid-binding Ig-like lectin 8 (SIGLEC8/SAF-2) is a ~54 kDa protein. Putative adhesion molecule that mediates sialic-acid dependent binding to blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. 1. Floyd, H. et al. (2000) The Journal of biological chemistry 275, 861-6. PMID: 10625619 2. Kikly, KK. et al. (2000) The Journal of allergy and clinical immunology 105, 1093-100. PMID: 10856141 3. Pröpster, JM. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E4170-9. PMID: 27357658
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.