Anti-Human Siglec-8 Recombinant Antibody (SAA0177) (HP983107)

Name: Anti-Human Siglec-8 Recombinant Antibody (SAA0177)
Brand: abinScience
SKU: HP983107
Price: 191 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.	HP983107
Species reactivity	Human
Applications	FCM, WB
Host species	Human
Isotype	IgG1, kappa
Clone ID	SAA0177
Clonality	Monoclonal
Target	SAF2, Sialoadhesin family member 2, SAF-2, Siglec-8, SIGLEC8, Sialic acid-binding Ig-like lectin 8
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9NYZ4
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Sialic acid-binding Ig-like lectin 8 (SIGLEC8/SAF-2) is a ~54 kDa protein. Putative adhesion molecule that mediates sialic-acid dependent binding to blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. 1. Floyd, H. et al. (2000) The Journal of biological chemistry 275, 861-6. PMID: 10625619 2. Kikly, KK. et al. (2000) The Journal of allergy and clinical immunology 105, 1093-100. PMID: 10856141 3. Pröpster, JM. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, E4170-9. PMID: 27357658
Note	For research use only.

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Bioactivity

SEC-HPLC detection for Anti-Human SIGLEC8/SAF-2 Antibody (ABS1401).
Western blot

Western blot analysis was performed using anti-SIGLEC8/SAF-2 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human SIGLEC8/SAF-2 (Catalog No: HP983011)
Lane 2: negative control