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| カタログ番号 | HP532013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, IF, IP | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA0227 | ||||
| ターゲット | SIR2-like protein 5, SIRT5, SIR2L5, Regulatory protein SIR2 homolog 5, NAD-dependent protein deacylase sirtuin-5, mitochondrial | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q9NXA8 | ||||
| RRID | Anti-Human SIRT5 IP Antibody (SAA0227) (abinScience Cat# HP532013, RRID:AB_3729761) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | NAD-dependent protein deacylase sirtuin-5, mitochondrial (SIRT5) is a ~33 kDa protein. NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. 1. Peng, C. et al. (2011) Molecular & cellular proteomics : MCP 10, M111.012658. PMID: 21908771 2. Du, J. et al. (2011) Science (New York, N.Y.) 334, 806-9. PMID: 22076378 3. Tan, M. et al. (2014) Cell metabolism 19, 605-17. PMID: 24703693 4. Yang, X. et al. (2018) Cancer research 78, 372-386. PMID: 29180469 5. Lin, ZF. et al. (2013) Biochemical and biophysical research communications 441, 191-5. PMID: 24140062 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human SIRT5 IP Antibody (SAA0227)
+86-027-65523339
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