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| カタログ番号 | HB725035 |
|---|---|
| 説明 |
Anti-Human SLC6A4 Monoclonal Antibody (1A667) [1A667] (HB725035) is a mouse monoclonal antibody detecting SLC6A4 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
| 種反応性 | Human |
| アプリケーション | ELISA, IHC, WB |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG |
| クローンID | 1A667 |
| 免疫原 | E. coli - derived recombinant human SLC6A4 (Ala181-Ser252). |
| ターゲット | Sodium-dependent serotonin transporter, SERT, 5HT transporter, 5HTT, Solute carrier family 6 member 4, SLC6A4 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P31645 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Sodium-dependent serotonin transporter (SLC6A4) is a ~70 kDa protein. Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling. Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse. 1. Mortensen, OV. et al. (1999) Brain research. Molecular brain research 71, 120-6. PMID: 10407194 2. Kilic, F. et al. (2003) Molecular pharmacology 64, 440-6. PMID: 12869649 3. Henry, LK. et al. (2011) The Journal of biological chemistry 286, 30823-30836. PMID: 21730057 4. Coleman, JA. et al. (2016) Nature 532, 334-9. PMID: 27049939 5. Hasenhuetl, PS. et al. (2016) The Journal of biological chemistry 291, 25864-25876. PMID: 27756841 6. Yang, D. et al. (2021) Science advances 7, eabl3857. PMID: 34851672 7. Brenner, B. et al. (2007) Journal of neurochemistry 102, 206-15. PMID: 17506858 8. Carneiro, AM. et al. (2008) The Journal of clinical investigation 118, 1544-52. PMID: 18317590 |
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human SLC6A4 Monoclonal Antibody (1A667)
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