Anti-Human SLC6A4/SERT Monoclonal Antibody (1A667) (HB725035)

Name: Anti-Human SLC6A4/SERT Monoclonal Antibody (1A667)
Brand: abinScience
SKU: HB725035
Price: 106 USD
Availability: InStock

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Каталожный номер	HB725035
Описание	Anti-Human SLC6A4 Monoclonal Antibody (1A667) [1A667] (HB725035) is a mouse monoclonal antibody detecting SLC6A4 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Реактивность видов	Human
Применения	ELISA, IHC, WB
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG
ID клона	1A667
Иммуноген	E. coli - derived recombinant human SLC6A4 (Ala181-Ser252).
Цель	Sodium-dependent serotonin transporter, SERT, 5HT transporter, 5HTT, Solute carrier family 6 member 4, SLC6A4
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P31645
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Sodium-dependent serotonin transporter (SLC6A4) is a ~70 kDa protein. Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling. Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse. 1. Mortensen, OV. et al. (1999) Brain research. Molecular brain research 71, 120-6. PMID: 10407194 2. Kilic, F. et al. (2003) Molecular pharmacology 64, 440-6. PMID: 12869649 3. Henry, LK. et al. (2011) The Journal of biological chemistry 286, 30823-30836. PMID: 21730057 4. Coleman, JA. et al. (2016) Nature 532, 334-9. PMID: 27049939 5. Hasenhuetl, PS. et al. (2016) The Journal of biological chemistry 291, 25864-25876. PMID: 27756841 6. Yang, D. et al. (2021) Science advances 7, eabl3857. PMID: 34851672 7. Brenner, B. et al. (2007) Journal of neurochemistry 102, 206-15. PMID: 17506858 8. Carneiro, AM. et al. (2008) The Journal of clinical investigation 118, 1544-52. PMID: 18317590
Примечание	For research use only.

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Anti-Human SLC6A4/SERT Monoclonal Antibody (1A667).pdf

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Anti-Human SLC6A4/SERT Monoclonal Antibody (1A667) (HB725035)

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