Anti-Human SPHK2 Polyclonal Antibody (HP741014)

Name: Anti-Human SPHK2 Polyclonal Antibody
Brand: abinScience
SKU: HP741014
Price: 168 USD
Availability: InStock

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Fiche technique
SDS

Aperçu

Numéro de catalogue

HP741014

Description

Anti-Human SPHK2 Polyclonal Antibody (HP741014) is a rabbit polyclonal antibody detecting SPHK2 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human SPHK2 (Gly170-His370).

Cible

SK2, Sphingosine kinase 2, SPHK2, SK 2, SPK 2

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9NRA0

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Sphingosine kinase 2 (SPHK2) is a ~69 kDa protein. Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides. In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis. In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration.

1. Igarashi, N. et al. (2003) The Journal of biological chemistry 278, 46832-9. PMID: 12954646

2. Don, AS. et al. (2009) Biochemical and biophysical research communications 380, 87-92. PMID: 19168031

3. Maceyka, M. et al. (2005) The Journal of biological chemistry 280, 37118-29. PMID: 16118219

4. Strub, GM. et al. (2011) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25, 600-12. PMID: 20959514

5. Hait, NC. et al. (2009) Science (New York, N.Y.) 325, 1254-7. PMID: 19729656

6. Okada, T. et al. (2005) The Journal of biological chemistry 280, 36318-25. PMID: 16103110

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human SPHK2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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