

| Número de catálogo | HP417014 | ||||||||
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| Descripción |
Anti-Human SPRY4 Polyclonal Antibody (HP417014) is a rabbit polyclonal antibody detecting SPRY4 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| Reactividad de especies | Human, Mouse | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human SPRY4 (Ser178-Arg270). | ||||||||
| Objetivo | Protein sprouty homolog 4, Spry-4, SPRY4 | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | Q9C004 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | Protein sprouty homolog 4 (SPRY4) is a ~32 kDa protein. Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1. Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin. 1. Leeksma, OC. et al. (2002) European journal of biochemistry 269, 2546-56. PMID: 12027893 2. Sasaki, A. et al. (2003) Nature cell biology 5, 427-32. PMID: 12717443 3. Tsumura, Y. et al. (2005) The Biochemical journal 387, 627-37. PMID: 15584898 | ||||||||
| Nota | For research use only. |
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