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| カタログ番号 | HC687013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1741 | ||||
| ターゲット | STIM1, Stromal interaction molecule 1, GOK | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q13586 | ||||
| RRID | Anti-Human STIM1 Antibody (SAA1741) (abinScience Cat# HC687013, RRID:AB_3727502) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Stromal interaction molecule 1 (STIM1) is a ~77 kDa protein. Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels. Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry. Involved in enamel formation. 1. Roos, J. et al. (2005) The Journal of cell biology 169, 435-45. PMID: 15866891 2. Liou, J. et al. (2005) Current biology : CB 15, 1235-41. PMID: 16005298 3. Zhang, SL. et al. (2005) Nature 437, 902-5. PMID: 16208375 4. Spassova, MA. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 4040-5. PMID: 16537481 5. Peinelt, C. et al. (2006) Nature cell biology 8, 771-3. PMID: 16733527 6. Soboloff, J. et al. (2006) The Journal of biological chemistry 281, 20661-20665. PMID: 16766533 7. Mercer, JC. et al. (2006) The Journal of biological chemistry 281, 24979-90. PMID: 16807233 8. Stathopulos, PB. et al. (2008) Cell 135, 110-22. PMID: 18854159 9. Yuan, JP. et al. (2009) Nature cell biology 11, 337-43. PMID: 19182790 10. Park, CY. et al. (2009) Cell 136, 876-90. PMID: 19249086 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human STIM1 Antibody (SAA1741)
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