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| カタログ番号 | HW747013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1636 | ||||
| ターゲット | Spleen tyrosine kinase, SYK, Tyrosine-protein kinase SYK, p72-Syk | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P43405 | ||||
| RRID | Anti-Human SYK Antibody (SAA1636) (abinScience Cat# HW747013, RRID:AB_3727397) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Tyrosine-protein kinase SYK is a ~72 kDa protein. Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. 1. Urzainqui, A. et al. (2002) Immunity 17, 401-12. PMID: 12387735 2. Wang, L. et al. (2021) Nature genetics 53, 500-510. PMID: 33782605 3. Chiu, CW. et al. (2002) The EMBO journal 21, 6461-72. PMID: 12456653 4. Shim, EK. et al. (2004) FEBS letters 575, 35-40. PMID: 15388330 5. M Gagné, L. et al. (2021) The Journal of biological chemistry 297, 101291. PMID: 34634301 6. Law, CL. et al. (1996) Molecular and cellular biology 16, 1305-15. PMID: 8657103 7. Ratthé, C. et al. (2004) Journal of leukocyte biology 76, 162-8. PMID: 15123770 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human SYK Antibody (SAA1636)
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