Anti-Human TICAM1 Polyclonal Antibody (HV815014)

Name: Anti-Human TICAM1 Polyclonal Antibody
Brand: abinScience
SKU: HV815014
Price: 168 USD
Availability: InStock

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Изображения
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Даташит
SDS

Обзор

Каталожный номер

HV815014

Описание

Anti-Human TICAM1 Polyclonal Antibody (HV815014) is a rabbit polyclonal antibody detecting TICAM1. Suitable for Human.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human TICAM1 (Met1-Cys144).

Цель

MyD88-3, PRVTIRB, Proline-rich, vinculin and TIR domain-containing protein B, Putative NF-kappa-B-activating protein 502H, TICAM-1, TICAM1, TIR domain-containing adapter molecule 1, TIR domain-containing adapter protein inducing IFN-beta, TRIF, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

Q8IUC6

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Фон

TIR domain-containing adapter molecule 1 (TICAM1) is a ~76 kDa protein. Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens.

1. Yamamoto, M. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 169, 6668-72. PMID: 12471095

2. Oshiumi, H. et al. (2003) Nature immunology 4, 161-7. PMID: 12539043

3. Han, KJ. et al. (2004) The Journal of biological chemistry 279, 15652-61. PMID: 14739303

4. Ye, W. et al. (2017) Journal of immunology (Baltimore, Md. : 1950) 199, 1856-1864. PMID: 28747347

5. Pallett, MA. et al. (2022) Viruses 14. PMID: 35215908

6. Liu, S. et al. (2015) Science (New York, N.Y.) 347, aaa2630. PMID: 25636800

Примечание

For research use only

Изображения

Western blot

Lane 1: Raji cell lysate

Ссылки

Даташит

Anti-Human TICAM1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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