Anti-Human TIGIT Recombinant Antibody (SAA0153), PE (HS739127)

Name: Anti-Human TIGIT Recombinant Antibody (SAA0153), PE
Brand: abinScience
SKU: HS739127
Price: 290 USD
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Número de catálogo	HS739127
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	SAA0153
Conjugación	PE
Objetivo	T-cell immunoreceptor with Ig and ITIM domains, TIGIT, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3, VSIG9, VSTM3
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Productos asociados	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), PE
Número de acceso	Q495A1
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades. _x005F_x000D_ _x005F_x000D_ 1. Yu, X. et al. (2009) Nature immunology 10, 48-57. PMID: 19011627 _x005F_x000D_ _x005F_x000D_ 2. Liu, S. et al. (2013) Cell death and differentiation 20, 456-64. PMID: 23154388 _x005F_x000D_ _x005F_x000D_ 3. Li, M. et al. (2014) The Journal of biological chemistry 289, 17647-57. PMID: 24817116 _x005F_x000D_ _x005F_x000D_ 4. Reches, A. et al. (2020) Journal for immunotherapy of cancer 8. PMID: 32503945
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.