Anti-Human TIGIT Recombinant Antibody (SAA0153), PE (HS739127)

Name: Anti-Human TIGIT Recombinant Antibody (SAA0153), PE
Brand: abinScience
SKU: HS739127
Price: 290 USD
Availability: InStock

データシート製品共有情報コピー

価格(USD):

スペック:

50T
100T

数量:

お問い合わせ

概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HS739127
種反応性	Human
アプリケーション	FCM
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1, kappa
クローンID	SAA0153
抱合	PE
ターゲット	T-cell immunoreceptor with Ig and ITIM domains, TIGIT, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3, VSIG9, VSTM3
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
関連製品	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), PE
アクセッション番号	Q495A1
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4, 50% glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades. _x005F_x000D_ _x005F_x000D_ 1. Yu, X. et al. (2009) Nature immunology 10, 48-57. PMID: 19011627 _x005F_x000D_ _x005F_x000D_ 2. Liu, S. et al. (2013) Cell death and differentiation 20, 456-64. PMID: 23154388 _x005F_x000D_ _x005F_x000D_ 3. Li, M. et al. (2014) The Journal of biological chemistry 289, 17647-57. PMID: 24817116 _x005F_x000D_ _x005F_x000D_ 4. Reches, A. et al. (2020) Journal for immunotherapy of cancer 8. PMID: 32503945
注意事項	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.