

| Número de catálogo | HD403014 | ||||||||
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| Descripción |
Anti-Human TMEM59 Polyclonal Antibody (HD403014) is a rabbit polyclonal antibody detecting TMEM59. Suitable for Mouse and Human.
Highlights
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| Reactividad de especies | Human, Mouse | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human TMEM59 (Gly45-Val135). | ||||||||
| Objetivo | C1orf8, Liver membrane-bound protein, TMEM59, Transmembrane protein 59 | ||||||||
| Nivel de endotoxinas | Please contact with the lab for this information. | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | Q9BXS4 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Fondo | Transmembrane protein 59 (TMEM59) is a ~36 kDa protein. Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. 1. Boada-Romero, E. et al. (2013) The EMBO journal 32, 566-82. PMID: 23376921 2. Boada-Romero, E. et al. (2016) Nature communications 7, 11821. PMID: 27273576 3. Ullrich, S. et al. (2010) The Journal of biological chemistry 285, 20664-74. PMID: 20427278 | ||||||||
| Nota | For research use only |
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