Human TMEM59 Recombinant Protein (N-His) (HD403012)

Name: Human TMEM59 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD403012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD403012
Description	Recombinant Human TMEM59 Protein, N-His (HD403012) expressed in E. coli, spanning Glu36-Ser238. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q9BXS4
Protein length	Glu36-Ser238
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	25.65 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	C1orf8, Liver membrane-bound protein, TMEM59, Transmembrane protein 59
Background	Transmembrane protein 59 is a ~36 kDa protein. Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. 1. Boada-Romero, E. et al. (2013) The EMBO journal 32, 566-82. PMID: 23376921 2. Boada-Romero, E. et al. (2016) Nature communications 7, 11821. PMID: 27273576 3. Ullrich, S. et al. (2010) The Journal of biological chemistry 285, 20664-74. PMID: 20427278
Note	For research use only

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Human TMEM59 Recombinant Protein (N-His).pdf

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Human TMEM59 Recombinant Protein (N-His) (HD403012)

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