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Anti-Human TMEM59 Polyclonal Antibody (HD403014)

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Overview
Catalog No.HD403014
Description
Anti-Human TMEM59 Polyclonal Antibody (HD403014) is a rabbit polyclonal antibody detecting TMEM59. Suitable for Mouse and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human TMEM59 (Gly45-Val135).
Target C1orf8, Liver membrane-bound protein, TMEM59, Transmembrane protein 59
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9BXS4
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Transmembrane protein 59 (TMEM59) is a ~36 kDa protein. Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.

1. Boada-Romero, E. et al. (2013) The EMBO journal 32, 566-82. PMID: 23376921
2. Boada-Romero, E. et al. (2016) Nature communications 7, 11821. PMID: 27273576
3. Ullrich, S. et al. (2010) The Journal of biological chemistry 285, 20664-74. PMID: 20427278
Note For research use only
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Datasheet
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Formula
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Anti-Human TMEM59 Polyclonal Antibody

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