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| カタログ番号 | HF504014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human TOM1 Polyclonal Antibody (HF504014) is a rabbit polyclonal antibody detecting TOM1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TOM1 (Met1-Gly148). | ||||||||
| ターゲット | Target of Myb1 membrane trafficking protein, Target of Myb protein 1, TOM1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O60784 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Target of Myb1 membrane trafficking protein (TOM1) is a ~53 kDa protein. Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways. Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures. Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes. MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN. Binds to polyubiquitinated proteins via its GAT domain. 1. Yamakami, M. et al. (2003) The Journal of biological chemistry 278, 52865-72. PMID: 14563850 2. Katoh, Y. et al. (2004) The Journal of biological chemistry 279, 24435-43. PMID: 15047686 3. Tumbarello, DA. et al. (2012) Nature cell biology 14, 1024-35. PMID: 23023224 4. Boal, F. et al. (2015) Journal of cell science 128, 815-27. PMID: 25588840 5. Xiao, S. et al. (2015) Structure (London, England : 1993) 23, 1910-1920. PMID: 26320582 6. Hu, S. et al. (2019) Nature communications 10, 3459. PMID: 31371777 | ||||||||
| 注意事項 | For research use only. |
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