Anti-Human TOM1 Polyclonal Antibody (HF504014)

Name: Anti-Human TOM1 Polyclonal Antibody
Brand: abinScience
SKU: HF504014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HF504014

Описание

Anti-Human TOM1 Polyclonal Antibody (HF504014) is a rabbit polyclonal antibody detecting TOM1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human TOM1 (Met1-Gly148).

Цель

Target of Myb1 membrane trafficking protein, Target of Myb protein 1, TOM1

Очистка

Purified by antigen affinity column.

Номер доступа

O60784

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Target of Myb1 membrane trafficking protein (TOM1) is a ~53 kDa protein. Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways. Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures. Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes. MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN. Binds to polyubiquitinated proteins via its GAT domain.

1. Yamakami, M. et al. (2003) The Journal of biological chemistry 278, 52865-72. PMID: 14563850

2. Katoh, Y. et al. (2004) The Journal of biological chemistry 279, 24435-43. PMID: 15047686

3. Tumbarello, DA. et al. (2012) Nature cell biology 14, 1024-35. PMID: 23023224

4. Boal, F. et al. (2015) Journal of cell science 128, 815-27. PMID: 25588840

5. Xiao, S. et al. (2015) Structure (London, England : 1993) 23, 1910-1920. PMID: 26320582

6. Hu, S. et al. (2019) Nature communications 10, 3459. PMID: 31371777

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human TOM1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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