Anti-Human TRIB3 Polyclonal Antibody (HA514014)

Name: Anti-Human TRIB3 Polyclonal Antibody
Brand: abinScience
SKU: HA514014
Price: 96 USD
Availability: InStock

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Каталожный номер

HA514014

Описание

Anti-Human TRIB3 Polyclonal Antibody (HA514014) is a rabbit polyclonal antibody detecting TRIB3 in ELISA, IHC, WB. Suitable for Bovine and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human TRIB3 (Ser66-Gln317).

Цель

TRIB3

Очистка

Purified by antigen affinity column.

Номер доступа

Q96RU7

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Альтернативные названия

Tribbles homolog 3, TRB-3, Neuronal cell death-inducible putative kinase, SINK, p65-interacting inhibitor of NF-kappa-B, TRIB3, C20orf97, NIPK, SKIP3, TRB3

Фон

Tribbles homolog 3 (TRIB3) is a ~39 kDa protein. Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity. Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation.

1. Ohoka, N. et al. (2005) The EMBO journal 24, 1243-55. PMID: 15775988

2. Ord, D. et al. (2005) Biochemical and biophysical research communications 330, 210-8. PMID: 15781252

3. Wu, M. et al. (2003) The Journal of biological chemistry 278, 27072-9. PMID: 12736262

4. Kiss-Toth, E. et al. (2004) The Journal of biological chemistry 279, 42703-8. PMID: 15299019

5. Aynaud, MM. et al. (2012) The Journal of biological chemistry 287, 39182-92. PMID: 22977230

Примечание

For research use only.

Изображения

Western blot

Western blot analysis was performed using anti-TRIB3 polyclonal antibody at 1ug/mL on various samples.
Lane 1: LO2 cell lysate
Lane 2: PC-3 cell lysate

Ссылки

Даташит

Anti-Human TRIB3 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-Human TRIB3 Polyclonal Antibody (HA514014)

Обзор

Изображения

Ссылки

Даташит

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