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| カタログ番号 | HC467014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human TRIM32 Polyclonal Antibody (HC467014) is a rabbit polyclonal antibody detecting TRIM32 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TRIM32 (Ser7-Arg101). | ||||||||
| ターゲット | E3 ubiquitin-protein ligase TRIM32, 2.3.2.27, 72 kDa Tat-interacting protein, RING-type E3 ubiquitin transferase TRIM32, Tripartite motif-containing protein 32, Zinc finger protein HT2A, TRIM32, HT2A | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13049 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | E3 ubiquitin-protein ligase TRIM32 is a ~71 kDa protein. E3 ubiquitin ligase that plays a role in various biological processes including neural stem cell differentiation, innate immunity, inflammatory resonse and autophagy. Plays a role in virus-triggered induction of IFN-beta and TNF by mediating the ubiquitination of STING1. Mechanistically, targets STING1 for 'Lys-63'-linked ubiquitination which promotes the interaction of STING1 with TBK1. Regulates bacterial clearance and promotes autophagy in Mycobacterium tuberculosis-infected macrophages. Negatively regulates TLR3/4-mediated innate immune and inflammatory response by triggering the autophagic degradation of TICAM1 in an E3 activity-independent manner. 1. Locke, M. et al. (2009) Human molecular genetics 18, 2344-58. PMID: 19349376 2. Di Rienzo, M. et al. (2019) Science advances 5, eaau8857. PMID: 31123703 3. Zhang, J. et al. (2012) The Journal of biological chemistry 287, 28646-55. PMID: 22745133 4. Romagnoli, A. et al. (2023) Cell death & disease 14, 505. PMID: 37543647 5. Yang, Q. et al. (2017) PLoS pathogens 13, e1006600. PMID: 28898289 6. Prajapati, P. et al. (2020) Cellular signalling 76, 109777. PMID: 32918979 7. Ryu, YS. et al. (2011) The Journal of biological chemistry 286, 25729-38. PMID: 21628460 8. Zhang, Q. et al. (2012) The Journal of biological chemistry 287, 20625-35. PMID: 22500027 10. Liu, J. et al. (2023) Cell reports 42, 113402. PMID: 37943659 | ||||||||
| 注意事項 | For research use only. |
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