Human TRIM32 Recombinant Protein (N-GST & C-His) (HC467022)

Name: Human TRIM32 Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: HC467022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC467022
Description	Recombinant Human TRIM32 Protein, N-GST & C-His (HC467022) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q13049
Protein length	Ser7-Arg101
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	72 kDa Tat-interacting protein, E3 ubiquitin-protein ligase TRIM32, EC:2.3.2.27, HT2A, RING-type E3 ubiquitin transferase TRIM32, TRIM32, Tripartite motif-containing protein 32, Zinc finger protein HT2A
Background	E3 ubiquitin-protein ligase TRIM32 is a ~71 kDa protein. E3 ubiquitin ligase that plays a role in various biological processes including neural stem cell differentiation, innate immunity, inflammatory resonse and autophagy. Plays a role in virus-triggered induction of IFN-beta and TNF by mediating the ubiquitination of STING1. Mechanistically, targets STING1 for 'Lys-63'-linked ubiquitination which promotes the interaction of STING1 with TBK1. Regulates bacterial clearance and promotes autophagy in Mycobacterium tuberculosis-infected macrophages. Negatively regulates TLR3/4-mediated innate immune and inflammatory response by triggering the autophagic degradation of TICAM1 in an E3 activity-independent manner. 1. Locke, M. et al. (2009) Human molecular genetics 18, 2344-58. PMID: 19349376 2. Di Rienzo, M. et al. (2019) Science advances 5, eaau8857. PMID: 31123703 3. Zhang, J. et al. (2012) The Journal of biological chemistry 287, 28646-55. PMID: 22745133 4. Romagnoli, A. et al. (2023) Cell death & disease 14, 505. PMID: 37543647 5. Yang, Q. et al. (2017) PLoS pathogens 13, e1006600. PMID: 28898289 6. Prajapati, P. et al. (2020) Cellular signalling 76, 109777. PMID: 32918979 7. Ryu, YS. et al. (2011) The Journal of biological chemistry 286, 25729-38. PMID: 21628460 8. Zhang, Q. et al. (2012) The Journal of biological chemistry 287, 20625-35. PMID: 22500027 10. Liu, J. et al. (2023) Cell reports 42, 113402. PMID: 37943659
Note	For research use only

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Datasheet

Human TRIM32 Recombinant Protein (N-GST & C-His).pdf

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Human TRIM32 Recombinant Protein (N-GST & C-His) (HC467022)

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