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| カタログ番号 | HF616014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human TRIM37 Polyclonal Antibody (HF616014) is a rabbit polyclonal antibody detecting TRIM37 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TRIM37 (Ser275-Ser405). | ||||||||
| ターゲット | E3 ubiquitin-protein ligase TRIM37, 2.3.2.27, Mulibrey nanism protein, RING-type E3 ubiquitin transferase TRIM37, Tripartite motif-containing protein 37, TRIM37, KIAA0898, MUL, POB1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O94972 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | E3 ubiquitin-protein ligase TRIM37 is a ~107 kDa protein. E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes. Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome. Has anti-HIV activity. 1. Kallijärvi, J. et al. (2005) Experimental cell research 308, 146-55. PMID: 15885686 2. Balestra, FR. et al. (2013) Developmental cell 25, 555-71. PMID: 23769972 3. Bhatnagar, S. et al. (2014) Nature 516, 116-20. PMID: 25470042 4. Wang, W. et al. (2017) The Journal of cell biology 216, 2843-2858. PMID: 28724525 5. Tabah, AA. et al. (2014) The Journal of general virology 95, 960-967. PMID: 24317724 | ||||||||
| 注意事項 | For research use only. |
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