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| カタログ番号 | HV509014 | ||||||||
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| 説明 |
Anti-Human TSC22D3 Polyclonal Antibody (HV509014) is a rabbit polyclonal antibody detecting TSC22D3 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Macaca fascicularis, Mus musculus, Human, and Sus scrofa.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TSC22D3 (Met1-Val134). | ||||||||
| ターゲット | TSC22D3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q99576 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | TSC22 domain family protein 3, DSIP-immunoreactive peptide, Protein DIP, hDIP, Delta sleep-inducing peptide immunoreactor, Glucocorticoid-induced leucine zipper protein, GILZ, TSC-22-like protein, TSC-22-related protein, TSC-22R, TSC22D3, DSIPI, GILZ | ||||||||
| 背景 | TSC22 domain family protein 3 (TSC22D3) is a ~14 kDa protein. Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities. In vitro, suppresses AP-1 transcription factor complex DNA-binding activities. 1. Asselin-Labat, ML. et al. (2004) Blood 104, 215-23. PMID: 15031210 2. Berrebi, D. et al. (2003) Blood 101, 729-38. PMID: 12393603 3. Ayroldi, E. et al. (2001) Blood 98, 743-53. PMID: 11468175 | ||||||||
| 注意事項 | For research use only. |
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