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| カタログ番号 | HB028014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human UGT2B7 Polyclonal Antibody (HB028014) is a rabbit polyclonal antibody detecting UGT2B7 in ELISA, IHC, WB. Suitable for Dog, Human, Macaca fascicularis, and Macaca mulatta.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human UGT2B7 (Ala285-Asp451). | ||||||||
| ターゲット | UGTB2B9, UDPGTh-2, UDPGT 2B9, UDP-glucuronosyltransferase 2B7, 3, 4-catechol estrogen-specific UDPGT, UGT2B7, UDPGT 2B7, UDP-glucuronosyltransferase 2B9 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P16662 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | UDP-glucuronosyltransferase 2B7 (UGT2B7) is a ~60 kDa protein. UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. 1. Samokyszyn, VM. et al. (2000) The Journal of biological chemistry 275, 6908-14. PMID: 10702251 2. Picard, N. et al. (2005) Drug metabolism and disposition: the biological fate of chemicals 33, 139-46. PMID: 15470161 3. Lépine, J. et al. (2004) The Journal of clinical endocrinology and metabolism 89, 5222-32. PMID: 15472229 4. Miley, MJ. et al. (2007) Journal of molecular biology 369, 498-511. PMID: 17442341 5. Alonen, A. et al. (2008) Biochemical pharmacology 76, 763-72. PMID: 18674515 6. Itäaho, K. et al. (2008) Drug metabolism and disposition: the biological fate of chemicals 36, 2307-15. PMID: 18719240 7. Sten, T. et al. (2009) Drug metabolism and disposition: the biological fate of chemicals 37, 417-23. PMID: 19022937 8. Sneitz, N. et al. (2013) Drug metabolism and disposition: the biological fate of chemicals 41, 582-91. PMID: 23288867 9. Perreault, M. et al. (2013) Drug metabolism and disposition: the biological fate of chemicals 41, 1616-20. PMID: 23756265 10. Kallionpää, RA. et al. (2015) The Journal of steroid biochemistry and molecular biology 154, 104-11. PMID: 26220143 | ||||||||
| 注意事項 | For research use only. |
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