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| カタログ番号 | HA158014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human USP37 Polyclonal Antibody (HA158014) is a rabbit polyclonal antibody detecting USP37 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human USP37 (Met1-Arg106). | ||||||||
| ターゲット | Ubiquitin carboxyl-terminal hydrolase 37, 3.4.19.12, Deubiquitinating enzyme 37, Ubiquitin thioesterase 37, Ubiquitin-specific-processing protease 37, USP37, KIAA1594 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q86T82 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ubiquitin carboxyl-terminal hydrolase 37 (USP37) is a ~110 kDa protein. Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response. Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1. 1. Yeh, C. et al. (2015) Current biology : CB 25, 2290-9. PMID: 26299517 2. Hernández-Pérez, S. et al. (2016) Molecular oncology 10, 1196-206. PMID: 27296872 3. Xiao, Z. et al. (2019) American journal of cancer research 9, 2749-2759. PMID: 31911859 4. Stromberg, BR. et al. (2021) The Journal of biological chemistry 297, 101184. PMID: 34509474 5. Huang, X. et al. (2011) Molecular cell 42, 511-23. PMID: 21596315 6. Wu, C. et al. (2021) Nucleic acids research 49, 11224-11240. PMID: 34606619 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-USP37 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse spleen lysate
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