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Anti-Human UVRAG Polyclonal Antibody (HA311014)

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Vista general
Número de catálogoHA311014
Descripción
Anti-Human UVRAG Polyclonal Antibody (HA311014) is a rabbit polyclonal antibody detecting UVRAG in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human UVRAG (Arg41-Ala164).
Objetivo UV radiation resistance-associated gene protein, p63, UVRAG
Purificación Purified by antigen affinity column.
Número de acceso Q9P2Y5
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

UV radiation resistance-associated gene protein (UVRAG) is a ~78 kDa protein. Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2.

1. Liang, C. et al. (2006) Nature cell biology 8, 688-99. PMID: 16799551
2. Liang, C. et al. (2008) Nature cell biology 10, 776-87. PMID: 18552835
3. Thoresen, SB. et al. (2010) Experimental cell research 316, 3368-78. PMID: 20643123
4. He, S. et al. (2013) Nature cell biology 15, 1206-1219. PMID: 24056303
5. Cheng, X. et al. (2017) Molecular cell 65, 1029-1043.e5. PMID: 28306502
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human UVRAG Polyclonal Antibody

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