Anti-Human UVRAG Polyclonal Antibody (HA311014)

Name: Anti-Human UVRAG Polyclonal Antibody
Brand: abinScience
SKU: HA311014
Price: 168 USD
Availability: InStock

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Aperçu

Numéro de catalogue

HA311014

Description

Anti-Human UVRAG Polyclonal Antibody (HA311014) is a rabbit polyclonal antibody detecting UVRAG in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human UVRAG (Arg41-Ala164).

Cible

UV radiation resistance-associated gene protein, p63, UVRAG

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9P2Y5

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

UV radiation resistance-associated gene protein (UVRAG) is a ~78 kDa protein. Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2.

1. Liang, C. et al. (2006) Nature cell biology 8, 688-99. PMID: 16799551

2. Liang, C. et al. (2008) Nature cell biology 10, 776-87. PMID: 18552835

3. Thoresen, SB. et al. (2010) Experimental cell research 316, 3368-78. PMID: 20643123

4. He, S. et al. (2013) Nature cell biology 15, 1206-1219. PMID: 24056303

5. Cheng, X. et al. (2017) Molecular cell 65, 1029-1043.e5. PMID: 28306502

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human UVRAG Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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