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| カタログ番号 | HA311014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human UVRAG Polyclonal Antibody (HA311014) is a rabbit polyclonal antibody detecting UVRAG in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human UVRAG (Arg41-Ala164). | ||||||||
| ターゲット | UV radiation resistance-associated gene protein, p63, UVRAG | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9P2Y5 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | UV radiation resistance-associated gene protein (UVRAG) is a ~78 kDa protein. Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2. 1. Liang, C. et al. (2006) Nature cell biology 8, 688-99. PMID: 16799551 2. Liang, C. et al. (2008) Nature cell biology 10, 776-87. PMID: 18552835 3. Thoresen, SB. et al. (2010) Experimental cell research 316, 3368-78. PMID: 20643123 4. He, S. et al. (2013) Nature cell biology 15, 1206-1219. PMID: 24056303 5. Cheng, X. et al. (2017) Molecular cell 65, 1029-1043.e5. PMID: 28306502 | ||||||||
| 注意事項 | For research use only. |
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