Anti-Human UVRAG Polyclonal Antibody (HA311014)

Name: Anti-Human UVRAG Polyclonal Antibody
Brand: abinScience
SKU: HA311014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HA311014

Описание

Anti-Human UVRAG Polyclonal Antibody (HA311014) is a rabbit polyclonal antibody detecting UVRAG in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human UVRAG (Arg41-Ala164).

Цель

UV radiation resistance-associated gene protein, p63, UVRAG

Очистка

Purified by antigen affinity column.

Номер доступа

Q9P2Y5

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

UV radiation resistance-associated gene protein (UVRAG) is a ~78 kDa protein. Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2.

1. Liang, C. et al. (2006) Nature cell biology 8, 688-99. PMID: 16799551

2. Liang, C. et al. (2008) Nature cell biology 10, 776-87. PMID: 18552835

3. Thoresen, SB. et al. (2010) Experimental cell research 316, 3368-78. PMID: 20643123

4. He, S. et al. (2013) Nature cell biology 15, 1206-1219. PMID: 24056303

5. Cheng, X. et al. (2017) Molecular cell 65, 1029-1043.e5. PMID: 28306502

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human UVRAG Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Mass

Concentration

Volume

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g/mol

Formula

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C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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