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| カタログ番号 | HP094014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human VAMP8 Polyclonal Antibody (HP094014) is a rabbit polyclonal antibody detecting VAMP8 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human VAMP8 (Glu2-Lys75). | ||||||||
| ターゲット | VAMP8, EDB, Endobrevin, VAMP-8, Vesicle-associated membrane protein 8 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9BV40 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Vesicle-associated membrane protein 8 (VAMP8) is a ~11 kDa protein. SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Also plays a role in regulated enzyme secretion in pancreatic acinar cells. 1. Itakura, E. et al. (2012) Cell 151, 1256-69. PMID: 23217709 2. Diao, J. et al. (2015) Nature 520, 563-6. PMID: 25686604 3. Polgár, J. et al. (2002) Blood 100, 1081-3. PMID: 12130530 4. van Tol, S. et al. (2020) Journal of virology 94. PMID: 31694946 | ||||||||
| 注意事項 | For research use only. |
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