Anti-Human WDR48 Polyclonal Antibody (HP117014)

Name: Anti-Human WDR48 Polyclonal Antibody
Brand: abinScience
SKU: HP117014
Price: 168 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HP117014

種反応性

Human, Mouse

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human WDR48 (Gly32-Lys358).

ターゲット

USP1-associated factor 1, WD repeat-containing protein 48, KIAA1449, WDR48, p80, WD repeat endosomal protein, UAF1

精製

Purified by antigen affinity column.

アクセッション番号

Q8TAF3

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

WD repeat-containing protein 48 (WDR48) is a ~76 kDa protein. Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. Also activates deubiquitinating activity of complexes containing USP12. In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability.

1. Cohn, MA. et al. (2007) Molecular cell 28, 786-97. PMID: 18082604

2. Cohn, MA. et al. (2009) The Journal of biological chemistry 284, 5343-51. PMID: 19075014

3. Yin, J. et al. (2015) Structure (London, England : 1993) 23, 2043-54. PMID: 26388029

4. Liang, F. et al. (2019) Nature communications 10, 2849. PMID: 31253762

5. Li, H. et al. (2016) Molecular cell 63, 249-260. PMID: 27373336

7. Gangula, NR. et al. (2013) The Journal of biological chemistry 288, 34545-54. PMID: 24145035

注意事項

For research use only.

イメージ

参考文献

データシート

Anti-Human WDR48 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-Human WDR48 Polyclonal Antibody (HP117014)

概要

イメージ

参考文献

データシート

SDS

クイックアクセス

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