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| カタログ番号 | HA146014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human YTHDF3 Polyclonal Antibody (HA146014) is a rabbit polyclonal antibody detecting YTHDF3 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human YTHDF3 (Gly416-Glu572). | ||||||||
| ターゲット | YTH domain-containing family protein 3, DF3, YTHDF3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q7Z739 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | YTH domain-containing family protein 3 (YTHDF3) is a ~63 kDa protein. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs. 1. Shi, H. et al. (2017) Cell research 27, 315-328. PMID: 28106072 2. Li, A. et al. (2017) Cell research 27, 444-447. PMID: 28106076 3. Yang, Y. et al. (2017) Cell research 27, 626-641. PMID: 28281539 4. Zaccara, S. et al. (2020) Cell 181, 1582-1595.e18. PMID: 32492408 5. Dominissini, D. et al. (2012) Nature 485, 201-6. PMID: 22575960 6. Wang, X. et al. (2014) Nature 505, 117-20. PMID: 24284625 7. Ries, RJ. et al. (2019) Nature 571, 424-428. PMID: 31292544 | ||||||||
| 注意事項 | For research use only. |
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