

| Каталожный номер | HP086014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human ZNF410 Polyclonal Antibody (HP086014) is a rabbit polyclonal antibody detecting ZNF410 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human ZNF410 (Arg76-Ser191). | ||||||||
| Цель | ZNF410, APA1, Another partner for ARF 1, Zinc finger protein 410, Zinc finger protein APA-1 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q86VK4 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Zinc finger protein 410 (ZNF410) is a ~52 kDa protein. Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells. Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells. May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence. May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose. However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4. 1. Lan, X. et al. (2021) Molecular cell 81, 239-254.e8. PMID: 33301730 2. Vinjamur, DS. et al. (2021) Nature genetics 53, 719-728. PMID: 33859416 3. Benanti, JA. et al. (2002) Molecular and cellular biology 22, 7385-97. PMID: 12370286 4. Chen, Y. et al. (2018) Journal of cellular physiology 234, 606-618. PMID: 30078215 | ||||||||
| Примечание | For research use only. |
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