Anti-IFN-alpha/beta R1 Polyclonal Antibody (HB823014)

Name: Anti-IFN-alpha/beta R1 Polyclonal Antibody
Brand: abinScience
SKU: HB823014
Price: 168 USD
Availability: InStock

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Каталожный номер

HB823014

Описание

Anti-IFNAR1 Polyclonal Antibody (HB823014) is a rabbit polyclonal antibody detecting IFNAR1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human IFNAR1 (Lys28-Asn227).

Цель

Interferon alpha/beta receptor 1, Cytokine receptor family 2 member 1, Cytokine receptor class-II member 1, CRF2-1, IFN-R-1, IFNAR1, IFNAR, IFN-alpha/beta receptor 1, Type I interferon receptor 1

Очистка

Purified by antigen affinity column.

Номер доступа

P17181

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Interferon alpha/beta receptor 1 (IFNAR1) is a ~63 kDa protein. Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes.

1. Russell-Harde, D. et al. (1999) Biochemical and biophysical research communications 255, 539-44. PMID: 10049744

2. Kumar, KG. et al. (2003) The EMBO journal 22, 5480-90. PMID: 14532120

3. Kumar, KG. et al. (2004) The Journal of biological chemistry 279, 46614-20. PMID: 15337770

4. Uzé, G. et al. (1990) Cell 60, 225-34. PMID: 2153461

5. Thomas, C. et al. (2011) Cell 146, 621-32. PMID: 21854986

6. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985

7. Hernandez, N. et al. (2019) The Journal of experimental medicine 216, 2057-2070. PMID: 31270247

8. Gothe, F. et al. (2022) Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 74, 136-139. PMID: 33252644

9. Bastard, P. et al. (2022) The Journal of experimental medicine 219. PMID: 35442418

10. Abramovich, C. et al. (1994) The EMBO journal 13, 5871-7. PMID: 7813427

Примечание

For research use only.

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