Anti-IL-11 Polyclonal Antibody (HB978014)

Name: Anti-IL-11 Polyclonal Antibody
Brand: abinScience
SKU: HB978014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Aperçu

Numéro de catalogue

HB978014

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human IL11 (Asp34-Leu199).

Cible

Adipogenesis inhibitory factor, AGIF, IL11, IL-11, Interleukin-11, Oprelvekin

Purification

Purified by antigen affinity column.

Numéro d'accès

P20809

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'.

1. Paul, SR. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 7512-6. PMID: 2145578

2. Harmegnies, D. et al. (2003) The Biochemical journal 375, 23-32. PMID: 12919066

3. Lamertz, L. et al. (2018) Science signaling 11. PMID: 30279168

Note

For research use only.

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