Anti-Human IL11 Reference Antibody (X203, RUO) (HB978016)

Name: Anti-Human IL11 Reference Antibody (X203, RUO)
Brand: abinScience
SKU: HB978016
Price: 176 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.	HB978016
Description	Anti-Human IL11 Antibody (X203) (HB978016) is a research-grade recombinant antibody targeting Adipogenesis inhibitory factor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1, kappa
Clone ID	X203
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Adipogenesis inhibitory factor, AGIF, IL11, IL-11, Interleukin-11, Oprelvekin
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P20809
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EnX203, EnX203, EnX-203, X203
Background	Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Paul, SR. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 7512-6. PMID: 2145578 2. Harmegnies, D. et al. (2003) The Biochemical journal 375, 23-32. PMID: 12919066 3. Lamertz, L. et al. (2018) Science signaling 11. PMID: 30279168
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human IL11 Antibody (X203).
Bioactivity

Detects Human IL11 in indirect ELISAs.
Bioactivity

Detects Recombinant Human IL11 Protein, N-His (Catalog No: HB978012) in indirect ELISAs.
Bioactivity

Detects Recombinant Human IL11 Protein, N-His (Catalog No: HB978022) in indirect ELISAs.
Bioactivity

Detects Recombinant Human IL11 Protein, N-His (Catalog No: HB978032) in indirect ELISAs.
Western blot

Western blot analysis was performed using anti-IL11 monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human IL11 (Catalog No: HB978012), 50ng
Lane 2: recombinant human IL11 (Catalog No: HB978012), 30ng
Western blot

Western blot analysis was performed using anti-/ monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant feline IL-11