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| カタログ番号 | HC627033 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||
| アプリケーション | IHC, WB | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | N1/66 | ||||
| ターゲット | CAMKG, CAMK-II, CAMK, CAMK2G, CaM kinase II subunit gamma, CaMK-II subunit gamma, Calcium/calmodulin-dependent protein kinase type II subunit gamma | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q63633 | ||||
| RRID | Anti-KCC2 Antibody (N1/66) (abinScience Cat# HC627033, RRID:AB_3728371) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Solute carrier family 12 member 5 (SLC12A5/KCC2) is a ~126 kDa protein. Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation. 1. Casula, S. et al. (2001) The Journal of biological chemistry 276, 41870-8. PMID: 11551954 2. Rivera, C. et al. (1999) Nature 397, 251-5. PMID: 9930699 3. Fiumelli, H. et al. (2013) Cerebral cortex (New York, N.Y. : 1991) 23, 378-88. PMID: 22345354 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-KCC2 Antibody (N1/66)
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