中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HF843014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-KDM4A Polyclonal Antibody (HF843014) is a rabbit polyclonal antibody detecting KDM4A/JMJD2A in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
|
||||||||
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human KDM4A (Tyr141-Lys310). | ||||||||
| ターゲット | Lysine-specific demethylase 4A, JMJD2, Jumonji domain-containing protein 2A, KDM4A, KIAA0677, JHDM3A, [histone H3]-trimethyl-L-lysine(9) demethylase 4A, [histone H3]-trimethyl-L-lysine(36) demethylase 4A, JMJD2A, JmjC domain-containing histone demethylation protein 3A | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75164 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Lysine-specific demethylase 4A (KDM4A/JMJD2A) is a ~120 kDa protein. Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Also able to demethylate histone H1-4 methylated at 'Lys-26' (H1.4K26me1, H1.4K26me2 and H1.4K26me3). 1. Whetstine, JR. et al. (2006) Cell 125, 467-81. PMID: 16603238 2. Bavetsias, V. et al. (2016) Journal of medicinal chemistry 59, 1388-409. PMID: 26741168 3. Tan, MK. et al. (2011) Molecular and cellular biology 31, 3687-99. PMID: 21768309 4. Trojer, P. et al. (2009) The Journal of biological chemistry 284, 8395-405. PMID: 19144645 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
