

| Каталожный номер | HF843014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-KDM4A Polyclonal Antibody (HF843014) is a rabbit polyclonal antibody detecting KDM4A/JMJD2A in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| Реактивность видов | Human, Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human KDM4A (Tyr141-Lys310). | ||||||||
| Цель | Lysine-specific demethylase 4A, JMJD2, Jumonji domain-containing protein 2A, KDM4A, KIAA0677, JHDM3A, [histone H3]-trimethyl-L-lysine(9) demethylase 4A, [histone H3]-trimethyl-L-lysine(36) demethylase 4A, JMJD2A, JmjC domain-containing histone demethylation protein 3A | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | O75164 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Lysine-specific demethylase 4A (KDM4A/JMJD2A) is a ~120 kDa protein. Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Also able to demethylate histone H1-4 methylated at 'Lys-26' (H1.4K26me1, H1.4K26me2 and H1.4K26me3). 1. Whetstine, JR. et al. (2006) Cell 125, 467-81. PMID: 16603238 2. Bavetsias, V. et al. (2016) Journal of medicinal chemistry 59, 1388-409. PMID: 26741168 3. Tan, MK. et al. (2011) Molecular and cellular biology 31, 3687-99. PMID: 21768309 4. Trojer, P. et al. (2009) The Journal of biological chemistry 284, 8395-405. PMID: 19144645 | ||||||||
| Примечание | For research use only. |
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